Diphenidine (also known as 1,2-DEP, DPD, DND) is a research chemical with theoretical dissociative propetries. The synthesis of Diphenidine was first reported in 1924 and employed a nitrile displacement reaction analogous to the one that would later be used to discover phencyclidine in 1956.
Diphenidine and related diarylethylamines have been studied in vitro as treatments for neurotoxic injury and are antagonists of the NMDA receptor.
Diphenidine’s highest theoretical affinity is for the NMDA receptor, but it would probably display some submicromolar affinity for the σ1 receptor, σ2 receptor and dopamine transporter.
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